So you have a long drive to Grandma's house and need to stop at a hotel on the way there for a night.  Pack one duffel bag with only the things you will need (for everyone) to stay the night at the hotel; pj's, change of clothes, toothbrush & paste, and hairbrush.  When you get to the hotel, you will only have to take ONE duffel bag in with you, instead of trying to drag everyone's bags in while wrangling all the kiddos.  So much easier!